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Open access Aug 2026

ACSL5 suppresses pancreatic cancer progression and gemcitabine resistance by regulating n-6 docosapentaenoic acid metabolism

Gemcitabine (GEM) resistance remains a major challenge in pancreatic ductal adenocarcinoma (PDAC) treatment. Metabolic reprogramming is a hallmark of tumors, and imbalance in lipid metabolism promotes tumor progression and drug resistance. This study aims to elucidate the mechanism of Acyl-CoA Synthetase Long C...

Yuan Chen, Zheng-Wang Wang, Ke Zhang et al. · 0 citations

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