Yuan-Dong Liu

Scaffold Hopping-Driven Discovery of Novel Thioether Fungicides: Design, SAR, and Computational Insights into Structure-Activity Relationships.

Sixty novel 5-(trifluoromethyl)-1,2,4-oxadiazole derivatives were designed by scaffold hopping from the diamide lead 6n and synthesized to examine ether, thioether, and sulfoxide linkers. Greenhouse assays against Phakopsora pachyrhizi identified FM-12818 (B5) as a leading thioether derivative, with an EC50 of 0.45 mg·...