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Yuan-Fang Chen

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Open access Oct 2026

Targeted lactate depletion via gluconeogenesis by engineered hepatocyte-based micronanorobots for radiosensitization and immune activation.

Radiotherapy is often limited by tumor-intrinsic DNA repair and an immunosuppressive microenvironment, both of which are reinforced by lactate accumulation. Here, we develop a CXCR4-engineered enucleated hepatocyte cytoplast platform decorated with Au-Pt Janus nanorobots (AP/LCCXCR4) to deplete intratumoral lactate and...

Yue-Yue Fan, Jia-Min Ye, Yuan-Fang Chen et al. · 0 citations

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