Author

Yuan-Fang Wu

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Review Open access Aug 2026

Cyclins and Cyclin‐Dependent Kinases: Structure, Biological Functions, and Innovative Targeting Strategies in Cancer

Cyclins and cyclin‐dependent kinases (CDKs) are frequently dysregulated in human cancers and represent compelling therapeutic targets. Beyond their well‐recognized roles in cell cycle control, CDK/cyclin complexes orchestrate diverse oncogenic processes, including transcription, genome maintenance, epigenetics, metabol...

Suya Zheng, Zhi-Peng Shen, Yuan-Fang Wu et al. · MedComm · 0 citations

Open access Aug 2026

Targeted degradation of P-TEFb via MDM2 substrate substitution collapses oncogenic transcriptional programs in MDM2-amplified cancers

MDM2 is an oncogenic E3 ubiquitin ligase best known for targeting the tumor suppressor p53 and is frequently amplified in human cancers, including dedifferentiated liposarcoma (DDLPS). We show that supraphysiological MDM2 expression can be exploited to reprogram its ligase activity toward selective degradation of o...

Ye Chen, Long Xie, Xian Guan et al. · Cell Death & Disease · 1 citation