Open access
Jul 2026
Intranasal drop of multiplex RNA therapy for SARS-CoV-2 infections: baicalein-enhanced FEN1 nuclease cleaving as a virus buster
An intranasal nanomedicine formulation comprising flap-endonuclease 1 and a panel of hairpin-structured DNA probes designed to concurrently target the highly conserved nucleocapsid RNA and host-derived Cathepsin L mRNA elicited a partial reduction in the viral load in mice infected with SARS-CoV-2, suggesting that this...
Jiyanuo Cao, Meng Wan, Jiayu Gu et al.
· Emerging Microbes and Infect... · 0 citations