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Sep 2026

N1-methylnicotinamide Mediates Multi-Target Cognitive Deficit Relief via AMPK-Lysosome Axis Regulation.

INTRODUCTION/OBJECTIVE Alzheimer's Disease (AD) progresses via interconnected Aβ aggregation, tau hyperphosphorylation, neuroinflammation, and lysosomal failure, while current single-target drugs only relieve cognitive symptoms without halting pathogenesis. Gut microbiota-derived N1-methylnicotinamide (MNAM) is associa...

Xiang-Jie Qiu, Qi-Lei Zhang, Yu-Ting Meng et al. · 0 citations

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