Author

Yuan Li

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Aug 2026

DHCR24+ tumor epithelial cells drive cisplatin resistance in bladder cancer by enhancing cholesterol metabolism to activate lipid raft-associated MAPK signaling

This study characterizes a specific DHCR24+ tumor epithelial subpopulation that orchestrates cisplatin resistance via the "cholesterol-lipid raft-MAPK" axis and establishes a clear mechanistic link between cholesterol metabolism and cisplatin sensitivity.

Yuan-Qiao Zhao, Zhuo Xing, Meng-Meng Wang et al. · Oncogene · 0 citations

Review Open access 2026

Nanomaterial-based optimization of chemo-radiotherapy for precisely overcoming PD-L1 resistance in the tumor immune microenvironment

This review explores sequential nanoregulation strategies based on different types of TME, and describes how functionalized nanocarriers, such as stimulus-responsive polymers, liposomes, and biomimetic nanoparticles, can be used to detect changes in the microenvironment, and to precisely deliver drugs when needed.

Bassam Lutf, Yuan Li, Jianliang Shen · BME Horizon · 0 citations