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The findings reveal that adaptive introgression can contribute to complex human adaptation through functionally convergent combinations of archaic variants, rather than only through shared large-effect haplotypes.
Previous limited characterization of short-read RNA-seq (srRNA-seq) accuracy in alternative splicing (AS) analysis due to methodological diversity and lack of reference standards, has left unclear how to achieve optimal performance—an issue increasingly critical with the rise of long-read sequencing. To address this, w...
Personalized neoantigen prediction is challenging due to the scarcity of positive samples, the noise of the experimental data, the severe class imbalance trait and the complex of immunogenicity features. Prior arts, such as linear regression and XGBoost fail to model long-range dependencies and contextual relationships...
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