Yuan-Xing Kuang

Remote desymmetrization of tetraoxacalix[2]arene[2]triazines enables the asymmetric synthesis of inherently chiral heteracalix[4]aromatics

The catalytic enantioselective synthesis of inherently chiral macrocycles remains a major challenge, particularly through non-cyclization strategies. Herein, we report a chiral phosphoric acid (CPA)-catalyzed remote desymmetrization of tetraoxacalix[2]arene[2]triazines, enabling access to inherently chiral heteracalix[...