Yuansheng Liu

ProMeta: Few-shot PROTAC-targeted degradation prediction across E3 ligases

Proteolysis-targeting chimeras (PROTACs) have emerged as a transformative therapeutic strategy that selectively degrades historically''undruggable''targets via the ubiquitin-proteasome system. Despite growing efforts to develop computational predictors of PROTAC degradation activity, existing supervised approaches rema...