Yuanxi Yu

MAXWELL: Calibrating the probabilistic outputs of protein language models to the mutation-induced stability change landscape

MAXWELL (Matrix-wise Landscape Learning), a novel post-training method that calibrates the probabilistic outputs learned by protein language models during pretraining to generate mutational landscapes that quantify the effects of individual amino acid substitutions on protein stability, is introduced.

PA-FedVL: A privacy-enhanced federated virtual learning framework based on label differential privacy distillation