Multi-Mechanistic Androgen Receptor Suppression by Chinese Medicine: A Polypharmacology Strategy Against Castration-Resistant Prostate Cancer
Castration-resistant prostate cancer (CRPC) is lethal because of persistent androgen receptor (AR) signaling, even when patients undergo androgen deprivation therapy. Resistance can arise through intratumoral androgen synthesis, AR overexpression, mutations in the ligand-binding domain, constitutively active splice...