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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Yuanyuan Ge

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Aug 2026

Structure-Guided CDR3 Insertion Enables Affinity Maturation of Naive Single-Domain Antibodies against Small-Molecule Haptens.

A "structure-guided directed modification" strategy was developed that focuses on conformational tuning rather than simple side-chain replacement to overcome the structural and energetic barriers inherent in hapten recognition and provide a practical and efficient computational framework for assisting the rapid evoluti...

Zeng-Lin Yang, Guo-Qiang Li, Yuanyuan Ge et al. · 0 citations

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