ABSTRACT
As global aging accelerates, sarcopenia has become an increasingly important public health concern. Although typically recognized as an age-related condition, sarcopenia can develop and progress more rapidly under certain pathological conditions, such as obesity and type 2 diabetes. With the ongoing advancemen...
Shuang Han, Qianqian Xiong, Qingqian Wu et al.· Chinese Medical Journal· 0 citations
As the key executioner protein of pyroptosis, GSDMD represents a promising yet underexplored therapeutic target for inflammatory diseases. In this study, we explored a PROTAC-based degradation approach targeting GSDMD for the treatment of pyroptosis-driven inflammatory conditions. Through screening of our in-house comp...
Qian-Qian Wang, Rong-Ying Hou, Yi-xuan Shua et al.· European journal of medicina...· 0 citations
Background After recanalization in acute ischemic stroke, cerebral ischemia/reperfusion injury (CI/RI) drives a cascade of pathophysiological events that worsen clinical outcomes, yet effective therapeutic options remain limited. Given the neuroprotective potential of Huperzine A (HupA), the efficacy of HupA injection...
Yu-Le Wang, Lin-Yun Xie, Yue Gao· Drug Design, Development and...· 0 citations
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