Hairpin-Structured DNAzyme-Initiated Spherical Hybridization Chain Reaction Cascade Enables Highly Sensitive Electrochemical Detection of MicroRNA
A homogeneous cascade amplification-based electrochemical biosensing platform that integrates hairpin-structured DNAzyme-assisted target recycling amplification with spherical hybridization chain reaction (SHCR)-enhanced electrochemical signal transduction, enabling highly sensitive detection of miRNA-141 (miR-141).