Fibrosis is a common end-stage pathological change across multiple chronic organ injuries and a primary driver of global organ failure and high mortality. Accumulating evidence indicates that the gut microbiota and its metabolites can bidirectionally regulate fibrosis progression through the gut–organ axis; however, a...
Yang Pan, Chang Shu, Yu-Qing Mei et al.· Frontiers in Microbiology· 0 citations
Antibody-drug conjugates (ADCs) rely on specific recognition of tumor-associated membrane receptors to achieve targeted intracellular drug delivery, yet in situ characterization of their interaction dynamics remains limited. Here, we develop a single-cell plasmonic imaging platform to quantitatively resolve the interac...
Findings provide the first evidence suggesting that increased mitochondrial fission via CaMKII/Drp1 signaling pathways in podocytes contributes to lenvatinib-induced kidney injury, and identify metformin as a clinically viable treatment option for lenvatinib-induced renal injury.