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Author

Yue Wei

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Aug 2026

Inhibition of nucleoporin 214 depletes leukemia stem cells by promoting heme catabolism and lipid peroxidation.

Chromosomal translocations involving nucleoporin (NUP) loci, such as NUP98 and NUP214, are recurrent in acute myeloid leukemia (AML). However, the intrinsic functions of wild-type nucleoporins in AML remain largely unknown. By screening the NUP family, we identified NUP214 as a frequently overexpressed gene and a criti...

Zhe Chen, Feng Wu, Wei Zhang et al. · 3 citations
Open access Sep 2026

High‐throughput identification of carboxylate‐free ligands for the E3 ligase Kelch domain‐containing protein 2

It is demonstrated that KLHDC2 can accommodate non-carboxylate scaffolds and expands the chemical space for developing KLHDC2-based targeted protein degradation strategies and expands the chemical space for developing KLHDC2-based targeted protein degradation strategies.

Yao Chen, Rui-Chen Gao, Jia-Jia Li et al. · 0 citations
Jul 2026

Structure-Guided Discovery of Novel Dual-Site FEM1B Ligands and Assessment of Their Use in Targeted Protein Degradation.

This work developed FL47, a dual-site ligand that combines extensive noncovalent interactions with targeted covalent engagement that exhibits submicromolar affinity, robust cellular target engagement, and markedly reduced cytotoxicity relative to previously reported covalent recruiters.

Ling-xiang Xu, Ruyi Huang, Yu-Ying Ma et al. · 0 citations

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