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Review Open access Aug 2026

Plant metabolites: potential treatments for ischemic acute kidney injury

Ischemia-reperfusion injury is a leading cause of acute kidney injury (AKI), which is characterized by high morbidity and mortality, as well as a substantial risk of progression to chronic kidney disease (CKD). Although supportive care has improved considerably, effective disease-modifying therapies are still lacking....

Yan Li, Wen-Ting Zhang, Sheng-Peng Zhang et al. · 0 citations
Open access Aug 2026

The Effect of Artemisinin on the Pharmacokinetics of Cyclophosphamide and Its Metabolite in Mice and Its Potential Mechanisms.

Cyclophosphamide (CP) is a common alkylating anticancer drug. Artemisinin (ART), an antimalarial agent metabolized by hepatic CYP450s, exhibits promising antitumor activity. This study established a rapid and accurate LC-MS/MS method for the quantitative analysis of CP and its metabolite in mouse plasma, as well as to...

Huilong Wang, Wenting Zhang, Haifeng Hu et al. · 0 citations

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