Sep 2026
Lipid nanoparticles optimized for large RNA cargo and tissue targeting enhance in vivo genome editing.
Song-Tao Dong, Fang-Lin Gong, Tyler Thomson et al.
· Nature Biotechnology · 0 citations
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Aug 2026
Lipid Nanoparticles Based Multi-Scale Systemic Immune Programming for Cancer Therapy.
A dual-track therapeutic paradigm that integrates tumor-directed immune activation with host physiological restoration is proposed, which positions LNP-based therapies to treat cancer as a systemic immune-metabolic disorder rather than a localized disease.
Xinwen Lin, Yong Li, Xi-Ling Shen et al.
· Molecular Therapy · 0 citations
Aug 2026
Nonviral delivery of chemically modified tRNA rescues nonsense mutations in cystic fibrosis.
This work combined site-specific chemical modification of sup-tRNAs with cargo-tailored pulmonary lipid nanoparticle (LNP) engineering to overcome barriers and restore cystic fibrosis transmembrane conductance regulator (CFTR) expression and function.
Jin-Gan Chen, Mu-Ye Zhou, Song-Tao Dong et al.
· Science · 2 citations