The GPX3‐VCAM1 Axis Gates Pro‐Fibrotic Tubule Cell Fate in Hyperuricemic Nephropathy
A genetically defined, multi‐hit mouse model that recapitulates the sustained hyperuricemia, metabolic dysregulation, and progressive fibrosis of human disease is established and glutathione peroxidase 3 (GPX3) is identified as a master regulator restraining precursor cell differentiation into Profib PT cells.