Rationally Designed Ru(II) Complex with Dual Type I/II ROS Generation for Hypoxia-Tolerant Photodynamic Therapy in Melanoma
The hypoxic tumor microenvironment of melanoma imposes a critical limitation on conventional type II photodynamic therapy (PDT), relying on oxygen for the generation of cytotoxic reactive oxygen species (ROS). To overcome this challenge, a donor-π-acceptor (D-π-A) bis-terpyridine ruthenium(II) complex, Ru(tpy)2TT, wa...