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Open access Sep 2026

Targeting BIRC6 rejuvenates hematopoietic stem cell aging and immunosenescence

Immunosenescence represents a central hallmark of organismal aging, characterized by a progressive decline in immune function, which compromises host defense and accelerates systemic aging. Hematopoietic stem cell (HSC) aging is a key contributor to this process, characterized by aberrant expansion, myeloid-biased diff...

Wei-Nian Liao, Fang-Ze Shao, Shao-Yan Wang et al. · 0 citations
Review Open access Aug 2026

Stem-like CD4 T cells in tumors: an emerging framework for antitumor immunity

Recent studies have identified antigen-experienced TCF1+PD-1+ lineage-negative (lin-) CD4 T cells in several tumor types. Strictly, stemness requires durable self-renewal and multipotent output demonstrated at the single-cell level; these criteria have not yet been established for an individual tumor-associated CD4 T c...

Jia-Xiang Xu, Yun-Chao Yang, Jun Zhang et al. · 0 citations

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