Yue-Zhang Wu

Estimating the Penetrance of PRNP Mutations in Chinese Prion Disease Patients based on the Genome Databases.

Genetic prion diseases (gPrDs) are directly caused by mutations in the prion protein gene (PRNP). Although several mutations have been strongly linked to disease manifestation, the penetrance of many variants remains uncertain. This study aimed to clarify the penetrance of PRNP variants by analyzing data from the Chine...