Author

Yue Zhou

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Open access Oct 2026

Synthesis, anti-Xanthomonas oryzae pv. oryzae activity and antibacterial mechanism of indole-3-substituted-1,3,4-oxadiazole derivative.

BACKGROUND Bacterial leaf blight (BLB) caused by Xanthomonas oryzae pv. oryzae (Xoo) seriously endangers global rice production. It is urgent to explore efficient and low-toxic antibacterial candidates for sustainable bacterial blight management. RESULTS Herein, 25 indole-3-substituted 1,3,4-oxadiazole derivatives we...

Meng-Zhi Yang, Xiao-Hua Wang, Yue Zhou et al. · Pest Management Science · 0 citations

Jul 2026

Design, Synthesis, and Mechanistic Investigation of Novel 1,3,4-Thiadiazole Derivatives Bearing a Morpholine Moiety Against Xanthomonas oryzae pv Oryzae.

Mechanical studies revealed H6 inhibits biofilm and extracellular polysaccharide formation, disrupts membrane integrity, induces ROS accumulation, and promotes lipid peroxidation, underscoring H6 as a promising bactericidal agent, demonstrating considerable potential in sustainable management of plant bacterial disease...

Mengzhi Yang, Cheng-Peng Li, Yue Zhou et al. · Journal of Agricultural and... · 0 citations

Aug 2026

Novel Piperlongumine derivatives exert multimodal antitumor effects in prostate cancer via MAPK pathway activation, poly-mechanistic apoptosis induction, and DNMT3A-mediated DNA methylation reduction.

In vivo validation in PC-3 xenograft mice confirmed that 11 M exerted robust tumor growth suppression with low systemic toxicity, accompanied by DNMT3A downregulation and MAPK pathway activation, substantiating its multi-target therapeutic mechanism.

Yu Zhang, Xue Yang, Xuemei Qiu et al. · Bioorganic chemistry (Print) · 0 citations