Yufeng Xiao

A 2-in-1 Strategy for the Discovery of Compact HDAC8 Protac Degraders

Proteolysis-targeting chimera (PROTAC) technology has emerged as a powerful therapeutic strategy in drug discovery. Conventional PROACs are heterobifunctional molecules composed of two distinct ligands that independently bind to a protein of interest (POI) and an E3 ligase. However, their inherently large molecular s...