Author

Yujie Wang

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Open access Aug 2026

YTHDC1 functions as a molecular chaperone to suppress ALS-linked hnRNPA1 mutants from aggregation

The RNA-binding protein YTHDC1 is identified as an ATP-independent molecular chaperone that prevents harmful protein aggregation, revealing a link between RNA regulation and protein quality control in neurodegeneration.

Kang Ren, Ming-Jie Cheng, Qiudan Luo et al. · Nature Communications · 0 citations