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Yujing Zhang

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Open access Aug 2026

Combined hydrogen and oxygen therapy attenuates vascular cognitive impairment in rats via gut microbiota-derived SCFA-GPR41/PI3K/Akt/Nrf2 signaling

It is found that HHOS significantly improved spatial memory and reduced anxiety-like behaviors in BCCAO rats, and outperformed monotherapies by coupling microbiota-SCFA restoration with GPR41/PI3K/Akt/Nrf2-mediated antioxidant defense, supporting a novel dual-gas strategy for VCI.

Xin-Lei Fu, Meng-Zhuo Ma, Yujing Zhang et al. · 0 citations

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