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Sponsored AI Networking Cookbook: Practical recipes for AI-assisted network automation and development AI Networking Cookbook: Practical recipes for AI-assisted network automation and development

Author

Yukihiko Sugita

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Open access Sep 2026

Step-by-step maturation mechanism of the binary toxin pore revealed by cryo-EM analysis.

Membrane pore-forming proteins (PFPs) form ring-shaped membrane-translocating oligomers on membranes, contributing to infection, immunity, and cell death functions. Binary toxins produced by some bacteria consist of an enzymatic component that acts as a toxin and a membrane-binding component that forms a pore that deli...

Tomohito Yamada, Ren Nakanishi, Yukihiko Sugita et al. · 0 citations
Preprint Aug 2026

A concentration-independent paradigm rendering weak interactions inherently quantifiable

The affinity-and-geometry readout enabled rational screening for protein-protein-interaction modulators, identifying compounds that enhance weak associations by reweighting local encounters rather than binding tightly on their own or forming a stable ternary complex.

Masahiko Yoshimura, Fuyuki Matsuda, Yoshiki Ikeda et al. · 0 citations

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