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Yukihisa Sawa

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Open access Sep 2026

Ozoralizumab, a trivalent anti-TNFα NANOBODY® compound, is resistant to rheumatoid factor-mediated modulation of FcRn-dependent recycling and immune complex uptake

Rheumatoid factor (RF), an autoantibody targeting IgG, is a key diagnostic marker of autoimmune diseases, especially rheumatoid arthritis (RA). In patients with RA, high RF titers have been reported to be associated with disease severity and may influence the pharmacological behavior and clinical response of certain...

Mai Morimoto, Yukihisa Sawa, Chihiro Ishiwatari-Ogata et al. · 0 citations

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