Berberine targets the PI3Kα LYS672 site to suppress the PI3K/Akt/NF-κB axis and modulate microglial functional states after intracerebral hemorrhage.
Microglia-driven neuroinflammation contributes to secondary injury after intracerebral hemorrhage (ICH). Modulating microglial functional states represents a promising therapeutic strategy. Berberine (BBR) has neuroprotective effects, but its role in ICH remains unclear. This study investigated whether BBR alleviates I...