Population pharmacokinetic/pharmacodynamic modeling of NH600001 reveals age-related differences in sedation response and supports individualized dosing in elderly patients.
BACKGROUND NH600001 is a novel intravenous anesthetic developed as a safer alternative to etomidate. Its pharmacokinetic/pharmacodynamic (PK/PD) profile and optimal dosing in elderly patients remain insufficiently characterized. This study aimed to develop a population PK/PD model of NH600001 and evaluate age‑related d...