DNA methylation (DNAm) plays a critical role in Alzheimer's disease (AD). Previous epigenome-wide association studies using 450K arrays captured limited CpG coverage and often focused on a single neuropathological measure. Here we profiled DNAm in 1,250 postmortem prefrontal cortex samples from the Rush Alzheimer's Dis...
G. Miao, Cheng Gao, Lei Yu et al.· Nature Aging· 0 citations
Summary Chronic, low-grade systemic inflammation is a polygenic trait captured with the INFLA-score, a composite of C-reactive protein, platelet count, leukocyte count, and granulocyte-to-lymphocyte ratio. We derived a polygenic risk score from the INFLA-score (iPRS) in a multi-ancestry population from the UK Biobank (...
H. Jandu, Ayo Olowofela, Megan M. Shuey et al.· HGG advances· 0 citations
Hi-C technologies are widely used to study genome-wide chromosome spatial organization. Among various Hi-C data analyses, detecting long-range chromatin interactions (i.e., 3D peak calling) is particularly critical due to its direct relevance to gene regulation. However, most existing peak callers fail to account for s...
Ling-Bo Zhou, Chang Chen, Jane Zizhen Zhao et al.· Methods and Protocols· 0 citations
A comprehensive three-dimensional epigenomic analysis of four main glial populations, including vRG, oRG, oligodendrocyte precursor cells and microglia, from the mid-gestational human neocortex identifies cell-type-specific candidate cis-regulatory elements (cCREs) and validated their regulatory function using transgen...
Ian R. Jones, Li Wang, M. Kosicki et al.· Nature· 0 citations
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