Author

Yun Liang

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Open access Oct 2026

Efficacy comparison of neoadjuvant chemotherapy, chemoradiotherapy, and chemoimmunotherapy in resectable esophageal squamous cell carcinoma: short- and long-term outcomes from a propensity score-matched analysis

This study consecutively enrolled patients with resectable locally advanced esophageal squamous cell carcinoma (ESCC) treated at Fujian Medical University Union Hospital and Gaozhou People's Hospital between January 1, 2,019, and January 1, 2022. All patients received neoadjuvant therapy followed by minimall...

Hai Zhang, Yun Liang, Chao-Lin Li et al. · Frontiers in Medicine · 0 citations

Review Open access Oct 2026

NEDD4-1: from molecular mechanisms to clinical translation in human diseases

Neural precursor cell expressed developmentally downregulated protein 4-1 (NEDD4-1), the founding member of the HECT family of E3 ubiquitin ligases, mediates substrate protein ubiquitination through its C2, WW, and HECT domains. It plays a key role in protein degradation via both the ubiquitin-proteasome system (UPS) a...

Hai-Fen Tian, Yong-Sheng Huang, Yun Liang et al. · Frontiers in Pharmacology · 0 citations