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Author

Yun-Qi Man

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Sep 2026

Inhalable mucus-penetrating and senescence-targeted nanoliposomes reverse senescence to overcome chemoresistance for enhanced lung cancer therapy.

Lung cancer therapy is severely hindered by the pulmonary mucus barrier and chemotherapy resistance driven by therapy-induced senescence (TIS) following DNA-damaging agents. Herein, we report an inhalable, mucus-penetrating nanoliposomes (DR@DPPC-Apt) engineered by incorporating an L1 cell adhesion molecule (L1CAM)-tar...

Yun-Qi Man, Yan-Fei Liu, Yong-Bo Liu et al. · 0 citations
Review Sep 2026

Multidimensional Regulatory Network of Cellular Senescence: From Mechanisms to Theranostics.

This review systematically maps the molecular architecture of the senescent-cell heterogeneity, off-target toxicity, and the lack of standardized biomarkers, and provides a framework for developing precision strategies to detect, modulate, or eliminate senescent cells in a context-appropriate manner.

Ze-Xiang Lv, Yan-Fei Liu, Yong-Bo Liu et al. · 0 citations

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