Oct 2026
Lineage tracing reveals asynchronous fate restriction in mouse embryos and stem cell-derived embryo models
Yun-Zheng Liu, Jihye Park, Laura Amaya et al.
· bioRxiv · 0 citations
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Open access
Aug 2026
Spatial second-order features predict glioma malignant transformation
Isocitrate dehydrogenase (IDH) mutant gliomas often transform from low to high grade aggressive tumors. The genetic and molecular drivers of this Malignant Transformation (MT) are poorly understood, and predicting whether a patient will undergo MT is an unmet challenge of high clinical relevance. To stratify patients b...
Michal Polonsky, Jonathan J. Fox, Yunrui Lu et al.
· bioRxiv · 0 citations
A Generative Virtual Tissue Model Enables Computational Design of Therapeutic Perturbation Strategies
Broadly, CIFM shows how generative artificial intelligence methods can be applied to model emergent behavior in highly interacting biological systems, yielding new approaches to fundamental understanding of tissue behavior as well as large-scale therapeutic design.
Yunrui Lu, Willis Zhang, Yu-Jen Chen et al.
· bioRxiv · 0 citations