Current mechanistic insights inspire targeted therapeutic strategies comprising α-synuclein inhibitors, mitochondrial protectants, anti-inflammatory agents, and novel cell death pathway blockers, alongside gut-brain axis interventions for PD, but these approaches face substantial challenges.
Abstract Amyotrophic lateral sclerosis (ALS) is a highly heterogeneous and fatal neurodegenerative disorder, for which clinical management and drug development have long faced formidable challenges. Since the approval of riluzole and edaravone, dozens of promising drug candidates that showed efficacy in preclinical mod...
Yutong Wei, Jie Wang, Ya-Nan Ji et al.· Drug Design, Development and...· 0 citations
Receptor-interacting protein kinase 3 (RIPK3) is classically recognized as a central executor of necroptosis, but accumulating evidence indicates that its functions extend beyond lytic cell death. RIPK3 regulates metabolic processes, inflammatory signaling, organelle homeostasis, and stress responses through both kinas...
Yun-Tian Shen, Haiyan Jiang, Jie Wang et al.· Biochemical Pharmacology· 0 citations
The molecular mechanisms underlying major cell death pathways are summarized and their context-dependent roles in skeletal muscle physiology are discussed, including development, adaptation, regeneration, and aging, as well as in disease progression.
Jiahuan Gong, Hong-Yi Xu, Yun-Tian Shen et al.· European Journal of Pharmaco...· 4 citations
BACKGROUND AND PURPOSE
The molecular mechanisms underlying denervation-induced muscle atrophy remain incompletely understood, and effective therapeutic interventions are currently lacking. Tectorigenin (TG), a natural isoflavonoid, has demonstrated antioxidant and metabolic regulatory activities. This study investigate...
Boya Liu, Fei Xue, Xingxing Fang et al.· British Journal of Pharmacol...· 0 citations
This review systematically elucidates the molecular activation mechanisms of the cGAS–STING pathway and its complex regulatory networks within tumors, with a particular focus on analyzing its dual functions—tumor immune surveillance versus tumor promotion—and the determining factors involved.
Haiyan Jiang, Zhanzhan Li, Xia Li et al.· Frontiers in Pharmacology· 2 citations
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