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Author

Yun-Xia Li

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Oct 2026

Development of Potent and Selective EGFR-PROTACs Based on Macrocyclic Fourth-Generation EGFR Inhibitors

Epidermal growth factor receptor (EGFR) mutant-driven non-small cell lung cancer (NSCLC) frequently develops acquired resistance to third-generation tyrosine kinase inhibitors (TKIs), particularly through the EGFR C797S mutation. Existing EGFR-targeting proteolysis-targeting chimeras (PROTACs) remain limited by unfav...

Qin-Yang He, Yan Cheng, Qing Zhang et al. · 0 citations
Open access Jul 2026

Structural Basis of Amyloid Fibril Assembly by Plant Seed Storage Proteins

The findings establish the molecular basis of amyloid formation in plant seeds and expand the structural landscape of amyloid fibrils beyond animal and microbial systems, providing a foundation for understanding amyloid formation in plant- and food-derived proteins.

Yiling Zhang, Dan-Ni Li, Qinyue Zhao et al. · 1 citation

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