BACKGROUND
Ischemic white matter injury (WMI) is a core pathological mechanism underlying vascular cognitive impairment, for which effective clinical interventions are currently lacking. The natural flavonoid glycoside Isoschaftoside (ISO) has been reported to exhibit various pharmacological activities, but its effects...
Cheng-Gang Li, Yu-Hao Xu, Huai-Ping Tang et al.· International Immunopharmaco...· 0 citations
Multiple sclerosis (MS) is an incurable and progressive inflammatory disease of the central nervous system (CNS) characterized by inflammatory demyelination, chronic axonal damage, and neurodegeneration. Carabrone (CA), a sesquiterpene lactone from the traditional Chinese herb Carpesium abrotanoides L., demonstrates di...
Huai-Ping Tang, Liang Sun, Bin Jia et al.· European Journal of Pharmaco...· 0 citations
Excessive activation of microglia exacerbates secondary brain injury after ischemic stroke, yet the upstream mechanisms governing this response remain incompletely understood. This study aimed to investigate the role of RIO kinase 3 (RIOK3) in microglia-mediated neuroinflammation after ischemic stroke and to explore th...
Yang Geng, Ningning Zong, Chao Zhou et al.· Experimental Neurology· 0 citations
Microglia are central mediators of neuroinflammation following ischemic stroke. Our previous multi‐omics data revealed significant upregulation of leukocyte immunoglobulin‐like receptor subfamily B member 4 (LILRB4) in microglia after transient middle cerebral artery occlusion (tMCAO), but its functional role remains u...
Jing-Long Hu, Mei-Juan Zhang, Pin-Yi Liu et al.· Glia· 0 citations
The NOD-like receptor family pyrin domain-containing protein 3 (NLRP3) inflammasome plays a crucial role in host defense; however, its aberrant activation leads to excessive release of pro-inflammatory cytokines, triggering inflammatory responses and tissue damage in human diseases. In this study, the inhibitory effect...
Bin Jia, Abuduwaili Zulalai, Huai-Ping Tang et al.· European Journal of Pharmaco...· 0 citations
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