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Author

Yun-Yuan Huang

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Open access Aug 2026

Covalent allosteric inhibition of AARS1 lactyltransferase

Alanyl-tRNA synthetase 1 (AARS1) was recently identified as a lactyltransferase responsible for protein lactylation, a modification associated with epigenetic regulation and metabolic adaptation. Here, we report compound XY353, which covalently binds C184 of AARS1, inducing steric clashes with F175 and triggering struc...

Yun-Yuan Huang, Si-Ying Liu, Lu-Yang Tian et al. · 0 citations
Aug 2026

Structure-Based Discovery of JN210 as a Potent Dual DCN1/HDAC Inhibitor for the Treatment of Nonsmall Cell Lung Cancer.

A dual-targeting strategy aimed at simultaneously inhibiting the oncogenic protein-protein interaction between UBE2M and DCN1, which is critical for neddylation-dependent activation of cullin-RING ligases (CRLs) and histone deacetylase (HDAC) activity is developed.

Tao Zheng, Yi-Gui Li, Yun-Yuan Huang et al. · 0 citations

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