Open access
Aug 2026
Histone lactylation encodes innate immune memory in atherosclerosis: a hypothesis of epigenetic bookmarking for residual inflammatory risk
It is proposed that cardiovascular risk factors stabilize HIF-1α, which drives glycolytic reprogramming and sustained lactate production and provides a mechanistic explanation for residual inflammatory risk, the observation that elevated cardiovascular events persist despite optimal lipid-lowering therapy.
Hao-Bo Yang, Yonghui Zhang, Yunfeng Yu et al.
· Clinical Epigenetics · 0 citations