Aug 2026
Inhibition of PARP-1 attenuates osteoarthritis progression by suppressing NF-κB signaling and alleviating chondrocyte senescence.
Osteoarthritis (OA) is a prevalent degenerative joint disease characterized by cartilage destruction, inflammation, and chondrocyte senescence, yet no disease-modifying therapies are currently available. Poly(ADP-ribose) polymerase-1 (PARP-1) has been implicated in inflammation and aging, but its role in OA pathogenesi...
Rui Zhang, Lingying Wang, Wen-Bin Pei et al.
· Cellular Signalling · 0 citations