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Author

Yuqi Zhang

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Open access Aug 2026

Single-cell transcriptomic landscape delineates pathogenic NK cell subpopulations and key mediators in systemic inflammatory response syndrome

Findings delineate dynamic NK subpopulation remodeling during SIRS and validate IGF1/IGF1R as a potential key pathway governing NK effector function, providing a transcriptomic basis for identifying candidate biomarkers and potential therapeutic targets in SIRS.

Hong-Ling Jia, Hang Zhao, Yan Li et al. · 0 citations
Open access Aug 2026

Integrative single-nucleus transcriptomic analysis identifies UBE2C+ proliferative tumor cells and immune-stromal regulatory crosstalk in small cell lung cancer

This study identified UBE2C+ proliferative tumor cells as a functionally relevant malignant subpopulation in SCLC and links this state to immune-stromal communication networks within the tumor microenvironment and provides a systems-level framework for investigating the cancer-immunity regulome in SCLC.

Hong-Ling Jia, Yongxuan An, Bing Chen et al. · 0 citations
Review Open access Jul 2026

Pleiotropic Roles of FBXO11 in Tumorigenesis: Implications for Targeted Therapy

By critically appraising its substrate diversity and functional versatility, it is proposed that FBXO11 be regarded not merely as a straightforward therapeutic target, but rather as a prognostic biomarker and a context‐specific vulnerability that necessitates precision medicine strategies for effective clinical interve...

Yuqi Zhang, Changyi Fan, Shiheng Chen et al. · 0 citations

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