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Yuriy Zaritskey

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Review Open access Sep 2026

Engineering controllable CAR T-cell therapies: from binary safety switches to programmable immunity

This review traces the conceptual evolution of CAR T-cell controllability from binary elimination towards platforms enabling graded, reversible, and spatiotemporally precise regulation, and proposes that the optimal next-generation CAR T product will integrate calibrated signalling, external control, and context-depend...

S. Smirnov, Yuriy Zaritskey, Galina Salogub et al. · 0 citations

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