Yusei Sato

Dimethylmalonate suppresses white adipocyte differentiation and ameliorates diet-induced obesity.

Obesity is driven by pathological expansion of white adipose tissue (WAT), reflecting both adipocyte hypertrophy and the differentiation of preadipocytes into mature white adipocytes. Arresting adipogenic differentiation is therefore a logical anti-obesity strategy. Because adipogenesis relies on extensive metabolic re...