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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Yuta Yoshino

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Sep 2026

Enhanced NRF1-mediated proteasome bounce-back and nelfinavir-mediated bortezomib sensitization in gemcitabine/cisplatin-resistant bladder cancer cells.

Findings identify enhanced NRF1-mediated proteasome adaptation as a feature of GC resistance and highlight the need for highly selective DDI2 inhibitors to evaluate DDI2-NRF1 targeting as a strategy to improve PI efficacy in drug-resistant solid cancers.

Atsumi Ota, M. Kawai, Rin Himura et al. · 0 citations
Open access Aug 2026

Cotinine Enhances Androgen Receptor Stability and Promotes Androgen-Dependent Proliferation in Prostate Cancer Cells: An In Vitro Study.

Cigarette smoking is associated with a poor prognosis and reduced efficacy of androgen receptor signaling inhibitors (ARSIs) in prostate cancer patients; however, the underlying molecular mechanisms remain largely undefined. This study investigated the impact of cotinine, the stable primary metabolite of nicotine, on a...

Riri Hayashi, Yudai Kudo, Yuta Yoshino et al. · 0 citations
Sep 2026

Upamostat potentiates bortezomib cytotoxicity and delays proteasome recovery in bortezomib-resistant malignant lymphoma cells through modulation of the DDI2/NRF1 axis.

Findings identify UMS as a candidate DDI2/NRF1-axis modulator that potentiates BTZ-induced cytotoxicity and delays functional proteasome recovery in BTZ-resistant malignant lymphoma cells.

Atsumi Ota, Sota Maruyama, Yudai Kudo et al. · 0 citations
Open access Jul 2026

Elevation of anticancer drug-induced cytotoxicity by velpatasvir through downregulation of claudin-14 expression in human colorectal cancer cells.

It is suggested that VEL enhances anticancer drug sensitivity in CRC cells through lysosome-dependent downregulation of CLDN14 protein and suppression of Nrf2-dependent oxidative stress responses.

Tomoka Ando, Yuko Mizukami, Shiemi Tosaki et al. · 0 citations

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