Oct 2026
Loss of Tars induces proteostasis stress and drives HSPC exhaustion through mTORC1 activation.
Ning-Zhe Li, Meng-Ke He, Qiang Wang et al.
· Acta Pharmacologica Sinica · 0 citations
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Aug 2026
Mutant p53 reactivation and DNA demethylation in the treatment of AML/MDS.
Acute myeloid leukemia/myelodysplastic syndromes (AML/MDSs) carrying p53 mutations are refractory to various standard therapies. Arsenic trioxide (ATO) may be effective in restoring function to p53 structural mutants. Here, we report that mutant p53 rescued by ATO treatment strengthened interferon responses triggered b...
Huaxin Song, Xin-Jie Chen, Shujun Xiao et al.
· Science Translational Medici... · 1 citation