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Author

Yutong Wei

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Review Open access Aug 2026

Therapeutic Challenges and Future Breakthroughs in Amyotrophic Lateral Sclerosis: From Precision Medicine to Innovative Trial Design

Abstract Amyotrophic lateral sclerosis (ALS) is a highly heterogeneous and fatal neurodegenerative disorder, for which clinical management and drug development have long faced formidable challenges. Since the approval of riluzole and edaravone, dozens of promising drug candidates that showed efficacy in preclinical mod...

Yutong Wei, Jie Wang, Ya-Nan Ji et al. · 0 citations
Review Aug 2026

The role and mechanisms of the cGAS-STING signaling pathway in age-related pathophysiological processes: challenges and therapeutic strategies.

The mechanisms of cGAS-STING activation in aging-including mitochondrial DNA leakage, nuclear envelope disruption, and retrotransposon activation-and its role in driving cellular senescence and the senescence-associated secretory phenotype (SASP) are reviewed.

Yutong Wei, Sutong Cai, Ya-Nan Ji et al. · 4 citations
Review Jul 2026

The central role of endoplasmic reticulum stress in Parkinson's disease and targeted therapeutic strategies.

This review systematically elaborates on the key pathological roles and molecular mechanisms of ERS and the triggered UPR in Parkinson's disease and discusses various intervention approaches, their research progress, and associated challenges.

Xin Chen, Zihao Zhao, Xinlei Yao et al. · 6 citations

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