Yuval Dotan

Widespread 3-Base Periodicity in Complex DNA Mixtures and an Alignment-Free Algorithm to Uncover its Source

Background Protein-coding DNA exhibits characteristic three-base periodicity. In unaligned DNA libraries, however, this signal should cancel if fragment boundaries are uniformly distributed across codon phases. Yet, we find that in multiple metagenomic libraries, base frequencies depended systematically on distance fro...