Author

Yu-Wei Zhang

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Open access Oct 2026

DIA Quantitative Proteomic Analysis Reveals Early Proteomic Responses to Honeybee-Derived Melittin in Murine Breast Cancer Cells

Breast cancer remains a major clinical challenge because of its molecular heterogeneity, therapeutic resistance, and disease recurrence. Melittin, the principal bioactive peptide of honeybee venom, exhibits antitumor activity in multiple experimental models; however, its early proteome-wide effects in breast cancer cel...

Jun-Ling Zhu, Wen-Hua Xu, He Zang et al. · Biology · 0 citations

Open access Aug 2026

Regulatory Manner and Role of Circular RNAs in the Microsporidian Invasion of Asian Honeybee

This study systematically uncovers the dynamic expression patterns and latent regulatory functions of microsporidian circRNAs during host infection for the first time, offering novel molecular targets and theoretical foundations for the prevention and treatment of honeybee microsporidiosis.

Xue Yang, J. Lei, Yu-Wei Zhang et al. · Animals · 0 citations

Jul 2026

ace-miR-3759-y Orchestrates Honeybee Larval Defense against Fungal Infection through Modulating Dual Targets and Oxidative Stress Response.

Chalkbrood disease, caused by Ascosphaera apis, threatens Apis cerana larvae. However, miRNA-mediated antifungal regulation remains poorly defined. Here, we characterized ace-miR-3759-y in A. apis-challenged A. cerana larvae. Stem-loop RT-PCR and Sanger sequencing confirmed its gut expression. Target prediction identif...

He Zang, Haimei Yue, Xiaoxue Fan et al. · Journal of Agricultural and... · 0 citations