Review
Open access
Aug 2026
Post-translational modifications in CD8+ T cell exhaustion: mechanisms, networks, and epigenetic locking
A PTM-driven signal–metabolism–epigenetic locking model is proposed as the central framework for understanding how PTMs govern CD8+ T cell exhaustion and lays a solid foundation for the development of next-generation immunotherapies.
Ting Yu, Meng-Juan Xia, Yuxia Wu et al.
· Frontiers in Immunology · 0 citations